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The efficacy of potential anticancer drugs during preclinical development is generally tested in vitro using cancer cells grown in monolayer; however, a significant discrepancy in their efficacy is observed when these drugs are evaluated in vivo. Thi...
Periodical:  Mol Pharm  2008/08/06
Authors:  Horning, J. L., Sahoo, S. K., Vijayaraghavalu, S., Dimitrijevic, S., Vasir, J. K., Jain, T. K., Panda, A. K., Labhasetwar, V.
Keywords:  Animals, Chick Embryo, Cross-Linking Reagents, dosage/*chemistry/metabolism/*pharmacology, Dose-Response Relationship, Drug, Fibrin/pharmacology, Ganglia, Spinal/drug effects/pathology/physiopathology, Hyaluronic Acid/administration &, Hydrogels/pharmacology, Male, Neurites/*drug effects/pathology, Rats, Rats, Sprague-Dawley, Recovery of Function, Spinal Cord Injuries/pathology/*physiopathology, Sulfhydryl Compounds/metabolism, Tissue Engineering/methods

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