Extending hepatocyte functionality for drug testing applications using high viscosity alginate encapsulated 3D cultures in bioreactors

(Eng)  

The maintenance of differentiated hepatocyte phenotype in vitro depends on several factors, in particular on extracellular matrix (ECM) interactions, e.g. with 3D matrices. Alginate hydrogel provides the cells with a good ECM due to the formation of ...

Periodical:  Tissue Eng Part C Methods  2010/02/27

Authors:  Miranda, J. P., Rodrigues, A., Tostoes, R. M., Leite, S. B., Zimmermann, H., Carrondo, M. J., Alves, P. M.